A. Ekbom et al., RISK OF PANCREATIC AND PERIAMPULLAR CANCER FOLLOWING CHOLECYSTECTOMY - A POPULATION-BASED COHORT STUDY, Digestive diseases and sciences, 41(2), 1996, pp. 387-391
An increased risk of pancreatic cancer following cholecystectomy has b
een reported in some studies but not in others. In order to settle thi
s question, a population-based cohort consisting of 62,615 patients wh
o had undergone cholecystectomy was followed up for the occurrence of
pancreatic and periampullar cancer up to 23 years. After excluding the
first year after operation, there were 261 pancreatic cancers vs 216.
8 expected [standardized incidence ratio (SIR) = 1.20; 95% confidence
interval (CI) = 1.06-1.37]; and 11 periampullar cancers vs 7.2 expecte
d (SIR = 1.52; 95% CI = 0.76-2.72). The increased risk of pancreatic c
ancer was most prominent up to four years after operation, but was als
o significantly increased 15 years or more after operation (SIR = 1.35
; 95% CI = 1.00-1.78). We conclude that there is a modest excess risk
of pancreatic and periampullar cancer following cholecystectomy, most
prominent up to four pears after operation, but that also exists 15 ye
ars or more after operation.