ESTIMATION OF STEADY-STATE ANTIBIOTIC CONCENTRATION IN CEREBROSPINAL-FLUID FROM SINGLE-DOSE KINETICS

Objective: Assuming linear kinetics, the mean CSF concentrations of an antibacterial in steady state (C-ssCSF) can be estimated, when the ar ea under the concentration-time curve in CSF after the first dose is k nown. For this purpose we propose the function C-ssCSF = AUC(CSF) Anti cipated dose/Dosing Interval Applied dose. Results: Together with the MIC and MBC of the causative pathogen, the estimate is of value in the choice of antibacterial drug and the dosing regimen in central nervou s system infections.