Dl. Knezevic et al., THE EFFICACY OF DIFFERENT DECONTAMINANTS IN RATS AND PIGS PERCUTANEOUSLY POISONED WITH ORGANOPHOSPHATES, Veterinary and human toxicology, 35(5), 1993, pp. 403-405
The efficacys of clay or alcoholate as decontaminants and a polyethyle
ne glycol + oxime N-octyl-pyridinium-4-aldoxime bromide (OPAB) protect
ive ointment were evaluated in rats and pigs percutaneously poisoned w
ith O-ethyl S-2-diisopropylaminoethyl methylphosphonothioate (VX) and
soman (GD) nerve gases. The use of protective ointment per se or combi
ned with the decontaminants protected all rats poisoned with GD, regar
dless of the experimental procedure. No poisoning or fatalities were o
bserved in pigs decontaminated 2 min later with clay or alcoholate, wh
ile the protective ointment delayed the onset of poisoning and even pr
evented death. The application of protective ointment, with or without
the use of decontaminants, significantly postponed the onset of poiso
ning in animals contaminated with VX. There was no significant differe
nce between procedures. Decontamination was very satisfactory and depe
ndent on the duration of exposure, being somewhat more efficient if pe
rformed by 30 min after exposure.