BIODEGRADATION OF POLYMER COMPOUNDS BASED ON CROSS-LINKED DEXTRANS

Authors
GUMARGALIEVA KZ SHIPUNOVA OV ZAIKOV GE JUBANOV BA MOSHKEVITCH SA
Citation
Kz. Gumargalieva et al., BIODEGRADATION OF POLYMER COMPOUNDS BASED ON CROSS-LINKED DEXTRANS, Polymer degradation and stability, 51(1), 1996, pp. 57-65
Citations number
10
Categorie Soggetti
Polymer Sciences
Journal title
Polymer degradation and stability → ACNP
ISSN journal
01413910
Volume
51
Issue
1
Year of publication
1996
Pages
57 - 65
Database
ISI
SICI code
0141-3910(1996)51:1<57:BOPCBO>2.0.ZU;2-9
Abstract
It is shown that cross-linked dextrans can be the basis for obtaining a drug reservoir which is a physiologically active polymer with the dr ug grafted to the matrix by chemical links. A drug form for treatment of tuberculosis has been obtained. The kinetics of drug release into m odel media and blood plasma has been investigated. It is found that po lymeric derivatives of isonyazide and kanamycin can be applied for the development of drug reservoirs with lower rate of release over a long period of time.