THE EFFICACY OF DIFFERENT FORMULATIONS OF PROTECTIVE-DECONTAMINATING OINTMENTS BASED ON POLYETHYLENE-GLYCOL IN RATS PERCUTANEOUSLY POISONEDWITH HIGHLY TOXIC ORGANOPHOSPHATES

Protective-decontaminating ointments based on polyethylene glycols (PE G) of different molecular weights were tested alone or with oxime N-oc tylpyridinium-4-aldoxime bromide, against percutaneous poisoning by th e nerve gases 0-ethyl S-2-diisopropyl methylphosphorothiolate and soma n in rats after 60 min exposure. PEG-based ointments consisting of hig her PEG combined with the oxime proved the most efficient for both poi sons. The combination of lower and medium PEG was somewhat less effici ent, while the formulation consisting of mostly lower PEG exerted prot ective effects only in soman poisoning.