THE EFFICACY OF DIFFERENT FORMULATIONS OF PROTECTIVE-DECONTAMINATING OINTMENTS BASED ON POLYETHYLENE-GLYCOL IN RATS PERCUTANEOUSLY POISONEDWITH HIGHLY TOXIC ORGANOPHOSPHATES
Dl. Knezevic et al., THE EFFICACY OF DIFFERENT FORMULATIONS OF PROTECTIVE-DECONTAMINATING OINTMENTS BASED ON POLYETHYLENE-GLYCOL IN RATS PERCUTANEOUSLY POISONEDWITH HIGHLY TOXIC ORGANOPHOSPHATES, Veterinary and human toxicology, 35(5), 1993, pp. 418-420
Protective-decontaminating ointments based on polyethylene glycols (PE
G) of different molecular weights were tested alone or with oxime N-oc
tylpyridinium-4-aldoxime bromide, against percutaneous poisoning by th
e nerve gases 0-ethyl S-2-diisopropyl methylphosphorothiolate and soma
n in rats after 60 min exposure. PEG-based ointments consisting of hig
her PEG combined with the oxime proved the most efficient for both poi
sons. The combination of lower and medium PEG was somewhat less effici
ent, while the formulation consisting of mostly lower PEG exerted prot
ective effects only in soman poisoning.