G. Owen et al., THE REPRODUCIBILITY OF URINARY GROWTH-HORMONE MEASUREMENT IN CHILDRENUNDERGOING ADENOTONSILLECTOMY - A PILOT-STUDY, Clinical otolaryngology and allied sciences, 21(1), 1996, pp. 54-58
The reproducibility of urinary growth hormone levels in normal childre
n and in children undergoing adenotonsillar surgery was investigated.
Thirty normal children and 32 children pre- and post-adenotonsillectom
y had overnight urinary growth hormone levels measured on two consecut
ive nights using the technique of immunoradiometric assay. There was n
o significant difference when levels in each of these groups were comp
ared. Therefore, the results were pooled (n = 94) and the correlation
coefficient comparing levels obtained on the first and the second cons
ecutive nights sample was calculated, r = 0.644 (P < 0.001). This work
suggests that studies of urinary growth hormone levels in children gi
ve reproducible results. Further investigation of this technique as a
screening or diagnostic procedure in the clinical setting can now be m
ore widely evaluated.