Absorption and excretion of iodixanol 320 mg I/ml were investigated in
rats after intragastric administration of 2.5 g I/kg b.w. Animals wer
e observed for up to 96 hours after treatment. and blood, urine and fe
ces taken at several time-points throughout the experiment. Concentrat
ions of iodixanol in serum and urine were measured by means of reverse
d-phase high-performance liquid chromatography. Fecal concentrations o
f iodixanol, based on iodine measurements, were determined by X-ray fl
uorescence spectrometry. Serial radiographs were obtained and histopat
hological examination was performed on selected tissues. The results i
ndicate that less than 1% of the intragastric dose of iodixanol is abs
orbed from the intestine into the blood stream. No adverse clinical si
gns were observed, and there were no treatment-related histomorphologi
cal findings.