ABSORPTION AND EXCRETION OF IODIXANOL AFTER INTRAGASTRIC ADMINISTRATION TO RATS

Absorption and excretion of iodixanol 320 mg I/ml were investigated in rats after intragastric administration of 2.5 g I/kg b.w. Animals wer e observed for up to 96 hours after treatment. and blood, urine and fe ces taken at several time-points throughout the experiment. Concentrat ions of iodixanol in serum and urine were measured by means of reverse d-phase high-performance liquid chromatography. Fecal concentrations o f iodixanol, based on iodine measurements, were determined by X-ray fl uorescence spectrometry. Serial radiographs were obtained and histopat hological examination was performed on selected tissues. The results i ndicate that less than 1% of the intragastric dose of iodixanol is abs orbed from the intestine into the blood stream. No adverse clinical si gns were observed, and there were no treatment-related histomorphologi cal findings.