LEUKOCYTE LIPID-PEROXIDATION, SUPEROXIDE-DISMUTASE, GLUTATHIONE-PEROXIDASE AND SERUM AND LEUKOCYTE VITAMIN-C LEVELS OF PATIENTS WITH TYPE-II DIABETES-MELLITUS

In the present study, leukocyte lipid peroxidation, superoxide dismuta se (SOD), glutathione peroxidase (GSH-Px) and serum and leukocyte vita min C levels of patients with type II diabetes mellitus and healthy co ntrols were investigated. Patients consisted of 53 cases (23 male, 30 female) aged 35-75 years and controls of 34 subjects (15 male, 19 fema le) aged 34-66 years. Leukocyte lipid peroxidation of diabetics was si gnificantly increased (P < 0.05) whereas vitamin C level was decreased (P < 0.05) compared to those of controls. There was no significant di fference in the other parameters. Also, there was no correlation betwe en the above parameters and HbA(1)c and glucose levels. Our results sh ow that leukocytes of diabetics are affected by oxidative stress which might be a reason for decreased microbicidal activity.