CLONING OF A PUTATIVE LIGAND FOR THE T1 ST2 RECEPTOR/

Authors
GAYLE MA SLACK JL BONNERT TP RENSHAW BR SONODA G TAGUCHI T TESTA JR DOWER SK SIMS JE
Citation
Ma. Gayle et al., CLONING OF A PUTATIVE LIGAND FOR THE T1 ST2 RECEPTOR/, The Journal of biological chemistry, 271(10), 1996, pp. 5784-5789
Citations number
31
Categorie Soggetti
Biology
Journal title
The Journal of biological chemistry → ACNP
ISSN journal
00219258
Volume
271
Issue
10
Year of publication
1996
Pages
5784 - 5789
Database
ISI
SICI code
0021-9258(1996)271:10<5784:COAPLF>2.0.ZU;2-T
Abstract
T1/ST2 is a receptor-like molecule homologous to the type I interleuki n-1 receptor. Despite this sequence similarity, me have been unable to demonstrate binding of T1/ST2 to any of the three interleukin-1 speci es. In searching for a ligand for T1/ST2, we have cloned a cell surfac e protein to which it binds. This protein is unable to initiate signal transduction by the T1/ST2 receptor in several in vitro assays.