PROTECTIVE EFFECTS OF GSH, VITAMIN-E, AND SELENIUM ON LIPID-PEROXIDATION IN CADMIUM-FED WATS

Increased intake of Cd results in its retention and in peroxidative da mage in soft tissues. Coadministration of antioxidants, viz., glutathi one (GSH), alpha-tocopherol, and Se, restricted the uptake and distrib ution of Cd in liver and kidney of rats. Moreover, no rise in malondia ldehyde was recorded. Although possible antioxidative mechanisms manif ested by GSH, alpha-tocopherol, and Se have been discussed, it is hypo thesized that GSH functions as a Cd chelator. Glutathione yielded favo rable effects in comparison to Se and alpha-tocopherol.