G. Kirtschig et al., BULLOUS PEMPHIGOID AND MULTIPLE-SCLEROSIS - A REPORT OF 3 CASES AND REVIEW OF THE LITERATURE, Clinical and experimental dermatology, 20(6), 1995, pp. 449-453
Three patients with longstanding multiple sclerosis (MS) who developed
bullous pemphigoid (BP) are reported. All patients had immunological
features of typical BP as determined by immunofluorescence and Western
immunoblotting studies. The clinical features however, differed from
those observed in typical BP. In two the BP started near an indwelling
catheter and two had striking involvement of the soles. None of our p
atients, or a further nine cases reported in the literature, had mucou
s membrane involvement. In MS patients BP appears to develop at a youn
ger age. Multiple drugs were taken by the MS patients; these, however,
appear not to play a role in triggering their BP. The course of BP in
patients with MS is moderate, although the majority require systemic
treatment.