We report the case of a 26-year-old man with haemophilia B and human i
mmunodeficiency virus infection (HIV) who presented with a short histo
ry of multiple dermatofibromas. He also had troublesome psoriasis for
which he was receiving acitretin with UVB therapy and had recently dis
continued low-dose daily prednisolone for associated arthropathy. Mult
iple dermatofibromas are rare and have been reported previously in ass
ociation with autoimmune disease, especially in individuals receiving
immunosuppressive therapy. We believe this to be the first report of m
ultiple dermatofibromas in an individual with advanced HIV infection a
nd propose that it may be related to his viral-mediated immunodeficien
cy, possibly augmented by UVB and systemic corticosteroid therapy.