Verucciform xanthoma is an unusual lesion characterized by verrucous e
pithelial proliferation accompanied by a prominent replacement of the
dermal papillae with foamy histiocytes. We describe a case of verrucif
orm xanthoma on the glans penis. The most striking histopathological f
inding was the presence of numerous acantholytic cells in the upper la
yers of the epithelium. We discuss the differential diagnosis with oth
er acantholytic disorders of the genital area and conclude that our fi
ndings can be interpreted as an additional example of incidental acant
holysis.