FNB DIAGNOSIS OF BREAST-CARCINOMA ASSOCIATED WITH HIV-INFECTION - A CASE-REPORT AND REVIEW OF HIV-ASSOCIATED MALIGNANCY

A 48 yr old HIV seropositive female presented with a right breast mass and bilateral axillary lymphadenopathy. Fine needle biopsy (FNB) reve aled an adenocarcinoma with abundant mucin production and features sug gestive of a cribriform and micropapillary ductal carcinoma in situ (D CIS). Histopathological examination of the tumor confirmed an invasive mixed colloid carcinoma with extensive DCIS. There have been 4 previo us reports in the literature of breast carcinoma associated with HIV s eropositivity. This case initially diagnosed by FNB is the first case reported in Australia. In spite of the somewhat more favourable histol ogical type of breast carcinoma, this tumor shows numerous unfavourabl e prognostic factors and has had an aggressive clinical course with re lapse of disease in the contralateral breast and distant metastases wi thin 4 wks of surgery, probably related to the patient's immunodeficie ncy.