EFFICACY OF CLARITHROMYCIN VERSUS THAT OF CLINDAMYCIN FOR SINGLE-DOSEPROPHYLAXIS OF EXPERIMENTAL STREPTOCOCCAL ENDOCARDITIS

Authors
VERMOT D ENTENZA JM VOUILLAMOZ J GLAUSER MP MOREILLON P
Citation
D. Vermot et al., EFFICACY OF CLARITHROMYCIN VERSUS THAT OF CLINDAMYCIN FOR SINGLE-DOSEPROPHYLAXIS OF EXPERIMENTAL STREPTOCOCCAL ENDOCARDITIS, Antimicrobial agents and chemotherapy, 40(3), 1996, pp. 809-811
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
3
Year of publication
1996
Pages
809 - 811
Database
ISI
SICI code
0066-4804(1996)40:3<809:EOCVTO>2.0.ZU;2-8
Abstract
Clarithromycin is compared with clindamycin for single-dose prophylaxi s of streptococcal endocarditis in rats. Human-like kinetics of the tw o antibiotics prevented endocarditis in animals challenged with both s mall and large amounts of bacterial inocula. Clarithromycin was margin ally superior to clindamycin against small amounts of inocula. Clarith romycin may be considered for endocarditis chemoprophylaxis in human.