Authors
Citation
S. Mabic et N. Castagnoli, REGIOSELECTIVE SYNTHESIS OF DEUTERATED ANALOGS OF THE NEUROTOXIN MPTP, Journal of labelled compounds & radiopharmaceuticals, 38(3), 1996, pp. 255-262
Citations number
11
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
ISSN journal
03624803
Volume
38
Issue
3
Year of publication
1996
Pages
255 - 262
Database
ISI
SICI code
0362-4803(1996)38:3<255:RSODAO>2.0.ZU;2-1
Abstract
1-Methyl-4-phenyl-2-pyridone has been used as starting material for th
e efficient and regioselective synthesis of deuterated analogues of th
e neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MPTP
-2,2-d(2), MPTP-6,6-d(2) and MPTP-2,2,6,6-d(4) were obtained in good y
ield through a combination of alkaline deuterium exchange and selectiv
e LiAlH4 and LiAlD4 reduction reactions.