GROWTH-INHIBITION OF METRONIDAZOLE-SUSCEPTIBLE AND METRONIDAZOLE-RESISTANT STRAINS OF GARDNERELLA-VAGINALIS BY LACTOBACILLI IN-VITRO

Authors
MCLEAN NW MCGROARTY JA
Citation
Nw. Mclean et Ja. Mcgroarty, GROWTH-INHIBITION OF METRONIDAZOLE-SUSCEPTIBLE AND METRONIDAZOLE-RESISTANT STRAINS OF GARDNERELLA-VAGINALIS BY LACTOBACILLI IN-VITRO, Applied and environmental microbiology, 62(3), 1996, pp. 1089-1092
Citations number
22
Categorie Soggetti
Microbiology,"Biothechnology & Applied Migrobiology
Journal title
Applied and environmental microbiology → ACNP
ISSN journal
00992240
Volume
62
Issue
3
Year of publication
1996
Pages
1089 - 1092
Database
ISI
SICI code
0099-2240(1996)62:3<1089:GOMAM>2.0.ZU;2-C
Abstract
Metronidazole resistance was produced in susceptible Gardnerella vagin alis after subculture in the presence of metronidazole. Metronidazole- resistant gardnerellae were less susceptible to growth inhibition by L actobacillus culture filtrates. A low pH (+/-4) and lactic acid accoun ted for 60 to 95% of inhibitory activity, and H2O2 accounted for only 0 to 30%. However, in the presence of myeloperoxidase, H2O2-producing lactobacilli decreased the viability of metronidazole-susceptible gard nerellae 2,000-fold.