AN ALTERNATIVE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ARRANGEMENT FOR DRUG QUALITY-CONTROL

The purpose was to develop and establish an original high-performance liquid chromatographic (HPLC) arrangement for the discrimination and e valuation of the components of a drug. The bulk ibuprofen drug powder was assayed as a model compound. The HPLC stationary phase was that of the P-cyclodextrin bond silica gel; the phosphate buffered drug solut ion was applied in the function of the HPLC mobile phase. The drug sam ples investigated were prepared by a procedure identical to that of th e eluent. On injecting the assayed sample into the eluent stream the c ontent of each drug component was estimated either from the positive o r negative HPLC detector response. Nil output signal indicates that in the sample analyzed the investigated component level is identical wit h the concentration of that component run in the HPLC mobile phase use d.