The lantibiotic compound nisin has a bacterial effect on gram positive
bacteria and was investigated for the possible use as a preservative
in topical formulations. For this reason, its minimal inhibitory conce
ntration (MIG) was determined in different types of ointments. Beside
its effect on gram positive bacteria it had also a bactericidal activi
ty on gram negative bacteria in concentrations of 0.06% (W/W). Within
the first month there was no detectable reduction of nisin activity in
different dermatological preparations. We conclude from these results
that the combination of nisin with fungicidal substances represents a
possible alternative to well known preservatives.