CEFTRIAXONE IN THE TREATMENT OF LYME NEUROBORRELIOSIS

In an open non-comparative clinical trial with the aim of evaluating t he clinical efficacy and safety of a 14 day course of 2 g ceftriaxone once daily, 46 patients with neuroborreliosis were entered at the Infe ctious Diseases Teaching Hospital in Prague 8. In 39 patients the diag nosis was early Lyme neuroborreliosis. Seven patients suffered from la te stage disease. Clinical results were 30% of patients cured at the e nd of treatment and 85% after 9 months in early stage disease. In late stage disease two patients out of seven were cured and four had impro ved after 12 months. One patient died because of cardiac infarction. I n no patient had treatment to be discontinued because of adverse react ions to antibiotics.