LONG-TERM RESULTS IN PATIENTS WITH LYME ARTHRITIS FOLLOWING TREATMENTWITH CEFTRIAXONE

A total of 35 patients with late stage Lyme borreliosis with involveme nt of the joints was followed up until 3 years after a 14 day course o f 2 g ceftriaxone once daily i.v. Diagnosis was confirmed by indirect and direct microbiological methods as well as clinical signs and sympt oms. Long term clinical results in 26 patients at 36 months were compl ete response or marked improvement in 19, relapse in six and new manif estations in four of the cases, respectively. Possible mechanisms for non-responding to therapy are discussed. Therapy was well tolerated; i n no case discontinuation of treatment was necessary due to adverse dr ug reactions. The treatment results in this group of 35 patients with Lyme arthritis are considered successful. The data obtained are consis tent with expectations based on the published experiences with ceftria xone in this indication.