NEURON-LIKE PHYSIOLOGICAL-PROPERTIES OF CELLS FROM HUMAN OLIGODENDROGLIAL TUMORS

One of the most common symptoms of patients with oligodendrogliomas is the high frequency of epileptic seizures. We thus studied the physiol ogical properties of cells in six human oligodendrogliomas and two oli goastrocytomas obtained from surgical material. The majority of tumor cells in living brain slices can generate action potentials as recorde d with the patch-clamp technique indicating that this tissue is domina ted by electrically excitable cells. In cultures from the same materia l, the action potential generating cells prevail within the first days and are subsequently replaced by electrically inexcitable cells. From histopathological and immunohistochemical data, the histogenesis of h uman oligodendroglial tumor is still uncertain. Our physiological stud y has not settled the debate on the origin of these tumors but reveale d important findings with regard to this question. Since action potent ial generating glial cells have not been described in situ so far thei r occurrence in oligodendroglial tumors implies that oligodendroglial tumor cells may belong to the neuronal cell lineage.