CUTIS-VERTICIS-GYRATA MENTAL DEFICIENCY SYNDROME - A PATIENT WITH DRUG-RESISTANT EPILEPSY AND POLYMICROGYRIA

Authors
STRIANO S RUOSI P GUZZETTA V PERONE L MANTO A CIRILLO S
Citation
S. Striano et al., CUTIS-VERTICIS-GYRATA MENTAL DEFICIENCY SYNDROME - A PATIENT WITH DRUG-RESISTANT EPILEPSY AND POLYMICROGYRIA, Epilepsia, 37(3), 1996, pp. 284-286
Citations number
14
Categorie Soggetti
Clinical Neurology
Journal title
Epilepsia → ACNP
ISSN journal
00139580
Volume
37
Issue
3
Year of publication
1996
Pages
284 - 286
Database
ISI
SICI code
0013-9580(1996)37:3<284:CMDS-A>2.0.ZU;2-O
Abstract
We report a case of cutis verticis gyratamental deficiency syndrome (C VG-MD) which was associated with drug-resistant epilepsy and bilateral occipital polymicrogyria. Genetic analysis showed an increased number of breaks at the 3p14 and 16q23 sites. We hypothesize that a deleteri ous factor acting at a critical period of intrauterine development cou ld result in the cerebral malformation and in the development of CVG. Neuroradiological investigation is warranted in cases of CVG-MD.