L-IDURONIC ACID-DERIVATIVES AS GLYCOSYL DONORS

O-[Methyl (2-O-acetyl-3-O-benzyl-4-O-levulinyl-alpha and beta-L-idopyr anosid)uronate] trichloroacetimidate and the corresponding n-pentenyl glycosides are efficient L-iduronic acid glycosyl donors. Both have be en used for the high-yielding synthesis of basic disaccharide blocks w hich are useful for the subsequent synthesis of complex oligosaccharid es related to heparin/heparan sulfate, and dermatan sulfate. In contra st, the corresponding thioethyl glycosides, thiophenyl glycosides, and fluoride, did not yield the expected disaccharides.