EFFECT OF ALPHA(1)-ACID GLYCOPROTEIN (ORO SOMUCOID) ON THE RESPIRATION OF LIVER-MITOCHONDRIA

Authors
SIROTA TV KUZMINA YG SIROTA NP
Citation
Tv. Sirota et al., EFFECT OF ALPHA(1)-ACID GLYCOPROTEIN (ORO SOMUCOID) ON THE RESPIRATION OF LIVER-MITOCHONDRIA, Biologiceskie membrany, 13(1), 1996, pp. 40-44
Citations number
25
Categorie Soggetti
Cell Biology
Journal title
Biologiceskie membrany → ACNP
ISSN journal
02334755
Volume
13
Issue
1
Year of publication
1996
Pages
40 - 44
Database
ISI
SICI code
0233-4755(1996)13:1<40:EOAG(S>2.0.ZU;2-3
Abstract
alpha(1)-Acid glycoprotein (orosomucoid), a well characterized acute p hase protein, was shown to inhibit the respiration of rat liver mitoch ondria which utilized succinate as an oxidation substrate. Orosomucoid inhibited both the ADP- and Ca2+-stimulated respiration of mitochondr ia. Orosomucoid was isolated from rat plasma by different methods. The observed effects of orosomucoid were suggested to be determined by a considerable negative charge of orosomucoid.