OF THE ROLES OF ATP AND GDP IN THE OF PHO TOINDUCED ACTIVATION OF 3',5'-CYCLIC GMP PHOSPHODIESTERASE BY RHODOPSIN FROM VERTEBRATE RETINA PHOTORECEPTOR-MEMBRANES
Vv. Furaev et al., OF THE ROLES OF ATP AND GDP IN THE OF PHO TOINDUCED ACTIVATION OF 3',5'-CYCLIC GMP PHOSPHODIESTERASE BY RHODOPSIN FROM VERTEBRATE RETINA PHOTORECEPTOR-MEMBRANES, Biologiceskie membrany, 13(1), 1996, pp. 110-112
Using a reconstructed system, composed of washed and illuminated bovin
e rod outer segment (ROS) membrane and nonpurified extract from ROS, A
TP was shown to activate phosphodiesterase with the same efficiency as
GTP at the concentrations down to 2 x 10(-6) M. In the presence of GD
P (10(-6) M), the phosphodiesterase activity can be significantly enha
nced by ATP (10(-6) M). The initial rate of the phosphodiesterase acti
vity in the presence of GTP (10(-6) M) was higher than that in the pre
sence of GppNHp at the same concentration.