ENANTIOSELECTIVE CHROMATOGRAPHY ON BRUSH-TYPE CHIRAL STATIONARY PHASES CONTAINING TOTALLY SYNTHETIC SELECTORS - THEORETICAL ASPECTS AND PRACTICAL APPLICATIONS

A family of totally synthetic, brush-type chiral stationary phases (CS Ps) for HPLC applications are available through a simple and flexible methodology based on the covalent attachment of chiral amines to oxira ne-activated silica microparticles. Tailored CSPs for specific classes of compounds can be obtained by a proper choice of the optically acti ve amine. Some typical features of the above phases are illustrated, w ith new results on the thermodynamics of CSP-solute interactions and o n the analysis of stereolabile compounds.