IDENTIFICATION OF 6 TAXINE ALKALOIDS FROM TAXUS-BACCATA NEEDLES

Authors
JENNISKENS LHD VANROZENDAAL ELM VANBEEK TA WIEGERINCK PHG SCHEEREN HW
Citation
Lhd. Jenniskens et al., IDENTIFICATION OF 6 TAXINE ALKALOIDS FROM TAXUS-BACCATA NEEDLES, Journal of natural products, 59(2), 1996, pp. 117-123
Citations number
24
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
2
Year of publication
1996
Pages
117 - 123
Database
ISI
SICI code
0163-3864(1996)59:2<117:IO6TAF>2.0.ZU;2-B
Abstract
Six taxine alkaloids were isolated from Taxus baccata needles and part ially separated. An HPLC method for the analysis of the taxine fractio n was developed. By NMR and deamination/hydrolysis studies it was esta blished that the taxine fraction consisted mostly of taxicin-I and tax icin-II derivatives in a variable ratio. Four of the six taxine alkalo ids isolated have not been reported before. All of the alkaloids were found to be unstable under neutral and basic conditions, and some of t hem were very easily interconverted.