A NEW CYTOTOXIC STEROL METHOXYMETHYL ETHER FROM A DEEP-WATER MARINE SPONGE SCLERITODERMA SP CF PACCARDI

Authors
GUNASEKERA SP KELLYBORGES M LONGLEY RE
Citation
Sp. Gunasekera et al., A NEW CYTOTOXIC STEROL METHOXYMETHYL ETHER FROM A DEEP-WATER MARINE SPONGE SCLERITODERMA SP CF PACCARDI, Journal of natural products, 59(2), 1996, pp. 161-162
Citations number
6
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
2
Year of publication
1996
Pages
161 - 162
Database
ISI
SICI code
0163-3864(1996)59:2<161:ANCSME>2.0.ZU;2-1
Abstract
24(R)-Methyl-5 alpha-cholest-7-enyl 3 beta-methoxymethyl ether (1), a new sterol ether, has been isolated from a deep-water marine sponge Sc leritoderma sp. cf. paccardi. Compound 1 exhibited in vitro cytotoxici ty against the cultured murine P-388 tumor cell line with an IC50 of 2 .3 mu g/mL. The isolation and structure elucidation of 1 by NMR spectr oscopy is described.