OBOVAMINE, A NEW INDOLE ALKALOID FROM STEMMADENIA-OBOVATA

The stem bark of the Panamanian plant Stemmademia obovata has afforded a new ibogaine-type alkaloid, obovamine (1), whose structure was dete rmined by a combination of spectral interpretation and chemical correl ations. Ten known alkaloids, coronaridine, coronaridine hydroxyindolen ine, voacangine, voacangine hydroxyindolenine, (19S)-heyneanine, (19S) -heyneanine hydroxyindolenine, (19S)-voacristine, (19S)-voacristine hy droxyindolenine, ajmalicine, and ajmalicinine, were also isolated. Voa cangine was the main alkaloid constituent.