TAXOL INDUCES BCL-2 PHOSPHORYLATION AND DEATH OF PROSTATE-CANCER CELLS

Treatment of prostate cancer cell lines expressing bcl-2 with taxol in duces bcl-2 phosphorylation and programmed cell death, whereas treatme nt of bcl-2-negative prostate cancer cells with taxol does not induce apoptosis. bcl-2 phosphorylation seems to inhibit its binding to bar s ince less bar was observed in immunocomplex with bcl-2 in taxol-treate d cancer cells. These findings support the use of the anticancer drug taxol for the treatment of bcl-2-positive prostate cancers and other b cl-2-positive malignancies, such as follicular lymphoma.