SPONTANEOUS REMISSION IN A PATIENT WITH THERAPY-RELATED MYELODYSPLASTIC SYNDROME (T-MDS) WITH MONOSOMY-7

We describe a case of spontaneously reversible refractory anaemia, a s ubtype of myelodysplastic syndrome (MDS), with monosomy 7 secondary to chronic treatment with azathioprine (AZA) in a young renal transplant recipient, AZA was stopped after that conventional cytogenetics and f luorescence in situ hybridization (FISH) had demonstrated the existenc e of a monosomy 7 clone. 4 months later, haematological values had con siderably improved and the karyotypic examination as well as the FISH analysis were normal. The spontaneous remission of this MDS with monos omy 7, which is usually associated with a particularly poor prognosis, could be due to the recovery of a better immunosurveillance following the withdrawal of AZA.