Background: Though it is rarely reported, decompression sickness (DCS)
is an expected risk for U-2 aviators. The potential for chronic seque
lae of untreated DCS in this population has never been addressed. Meth
ods: After conducting a preliminary survey at an active-duty U-2 squad
ron, a cohort of 416 U-2 pilots (active-duty and retired) were mailed
two sequential anonymous surveys to assess demographic data, career pr
evalence of DCS symptoms, and overall health status with an emphasis o
n chronic musculoskeletal problems. Results The response rate for each
mail-in survey was over 60%. During their career, 75.5% of pilots exp
erienced DCS symptoms such as joint pain, skin manifestations, and/or
various neurological problems. Symptoms generally started during fligh
t and resolved upon descent. Many pilots voluntarily increased their o
xygen prebreathing time, or inflated the pressure suit during flight t
o prevent or treat symptoms. At some point in their career 12.7% of th
ose experiencing symptoms either altered the flight profile or aborted
a mission as a result The association of past DCS with current arthri
tic problems was not statistically significant. Conclusions The career
prevalence of DCS symptoms in U-2 pilots is higher than previously re
ported, and these symptoms sometimes affect mission completion. We fou
nd no evidence that chronic musculoskeletal sequelae (e.g., arthritis
or dysbaric osteonecrosis) are causally associated with DCS in this po
pulation.