THE COMPARISON OF INJECTION SITE REACTIONS CAUSED BY 2 COMMERCIAL MULTIVALENT CLOSTRIDIAL VACCINES

Two groups of cattle were used in this study comparing injection site reactions caused by two commercial multivalent clostridial vaccines. i nfection procedure, bodyweight, injection reaction, and subcutaneous d epth were considered. Significant differences in injection reaction si ze between the two vaccines were demonstrated. While the majority of c attle had some swelling at the injection site 7 and 30 days after vacc ination, subcutaneous injection with product B resulted in a smaller i njection reaction area and subcutaneous depth 30 days after vaccinatio n, when compared with product A. Furthermore, there was a significant reduction in injection reaction area and subcutaneous depth between Da ys 7 and 30 after treatment with product B; whereas there was no signi ficant change seen with product A during that time. While the relative efficacy of the vaccines was not addressed in this study, both produc ts have satisfied appropriate approval requirements. Assuming similar potency and efficacy, usage of less reactive products, which are cost- competitive, would be of obvious advantage to the cattle industry.