EXPRESSION OF PROTEIN ENCODED BY VARICELLA-ZOSTER VIRUS OPEN READING FRAME-63 IN LATENTLY INFECTED HUMAN GANGLIONIC NEURONS

Authors
MAHALINGAM R WELLISH M COHRS R DEBRUS S PIETTE J RENTIER B GILDEN DH
Citation
R. Mahalingam et al., EXPRESSION OF PROTEIN ENCODED BY VARICELLA-ZOSTER VIRUS OPEN READING FRAME-63 IN LATENTLY INFECTED HUMAN GANGLIONIC NEURONS, Proceedings of the National Academy of Sciences of the United Statesof America, 93(5), 1996, pp. 2122-2124
Citations number
20
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
93
Issue
5
Year of publication
1996
Pages
2122 - 2124
Database
ISI
SICI code
0027-8424(1996)93:5<2122:EOPEBV>2.0.ZU;2-#
Abstract
The ganglionic cell type in which varicellazoster virus (VZV) is laten t in humans was analyzed by using antibodies raised against in vitro-e xpressed VZV open reading frame 63 protein, VZV open reading frame 63 protein was detected exclusively in the cytoplasm of neurons of latent ly infected human trigeminal and thoracic ganglia. This is, to our kno wledge, the first identification of a herpesvirus protein expressed du ring latency in the human nervous system.