CORE ASSESSMENT PROGRAM FOR INTRACEREBRAL TRANSPLANTATION IN HUNTINGTONS-DISEASE (CAPIT-HD)

Studies in Parkinson's disease using the Core Assessment Program for I ntracerebral Transplantation (CAPIT) protocol have demonstrated that g rafts of embryonic mesencephalic cells into striatum can survive, grow , and exert useful clinical effects. Attention is now being directed t oward neural grafting in other conditions, such as Huntington's diseas e. As a precondition for grafting of embryonic striatal cells into dis eased striatum in this complex motor and psychiatric disorder, not onl y is further basic research needed, but also a thorough and wide-rangi ng assessment protocol is essential. This article presents such a CAPI T-HD assessment protocol.