EFFECTS OF PROSPECTIVE, RANDOMIZED CHOLESTEROL-LOWERING DIETARY INTERVENTION AND APOLIPOPROTEIN-E PHENOTYPE ON SERUM LIPOPROTEIN(A) CONCENTRATIONS OF INFANTS AGED 7-24 MO

A high serum lipoprotein(a) [Lp(a)] concentration is associated with i ncreased risk of coronary artery disease. Few external factors are abl e to markedly modify serum Lp(a) concentrations. The aim of this study was to evaluate how serum Lp(a) concentrations of infants between 7 a nd 24 mo of age change in a cholesterol-lowering dietary intervention, and to assess the influence of apolipoprotein (ape) E phenotypes on s erum Lp(a) concentrations. The intervention children (n = 394) had ser um cholesterol, non-high-density-lipoprotein cholesterol, and choleste rol corrected for Lp(a)-cholesterol values (P for all < 0.001) lower t han those of the control children (n = 390), but median serum Lp(a) co ncentrations at the age of 24 mo were not different from those of cont rol children. Serum Lp(a) values differed according to the apo E pheno type as tile median Lp(a) values increased from E2/2 to E3/2, E4/2, E3 /3, E4/3, and to E4/4 (P for the difference = 0.023, Mann-Whitney U te st). Our results suggest that apo E phenotype influences serum Lp(a) c oncentrations noticeably, but the effect of the cholesterol-lowering d ietary intervention was not significant in subjects aged 24 mo.