PERIODIC LATERALIZED EPILEPTIFORM DISCHARGES IN MULTIPLE-SCLEROSIS

We report an unusual cause of periodic lateralized epileptiform discha rges (PLEDs) in a young man with a long history of multiple sclerosis. Two exacerbations of multiple sclerosis, 3 years apart, were complica ted by complex partial status epilepticus. After each episode, serial electroencephalograms revealed PLEDs (right frontal PLEDs in the first episode and right frontotemporal and bifrontal PLEDs in the second on e), which resolved within 2 weeks. With the first episode, magnetic re sonance imaging revealed an enhancing white matter lesion in the right frontal area, which improved after 3 weeks. We concluded that in each instance an exacerbation of multiple sclerosis caused the seizures.