ANTIBODY-DEPENDENT CYTOTOXIC ACTIVITY ON HUMAN CANCER-CELLS EXPRESSING UK-114 TUMOR MEMBRANE ANTIGEN

Authors
BARTORELLI A BUSSOLATI B MILLESIMO M GUGLIOTTA P BUSSOLATI G
Citation
A. Bartorelli et al., ANTIBODY-DEPENDENT CYTOTOXIC ACTIVITY ON HUMAN CANCER-CELLS EXPRESSING UK-114 TUMOR MEMBRANE ANTIGEN, International journal of oncology, 8(3), 1996, pp. 543-548
Citations number
20
Categorie Soggetti
Oncology
Journal title
International journal of oncology → ACNP
ISSN journal
10196439
Volume
8
Issue
3
Year of publication
1996
Pages
543 - 548
Database
ISI
SICI code
1019-6439(1996)8:3<543:ACAOHC>2.0.ZU;2-6
Abstract
The monoclonal antibody (P-3 mAb) and the rabbit immune sera (RIS) rec ognizing a 14 kDa perchloric acid soluble protein extracted from goat liver (UK 114), locate this antigen on the cell membrane of several hu man cancer cell lines. UK 114-positive cells (e.g. HT 29 and KATO VI c ells) undergo antibody-dependent cytolysis bl vitro. In nu/nu mice bea ring xenografted HT 29 cells, tumor growth was markedly impaired by pe ri-tumoral injection of anti-UK 114 antibodies. These experiments sugg est that human tumors expressing UK 114 over the cell membrane may und ergo antibody-mediated cytolysis and growth control.