Chronic depression is a prevalent but under-recognized and under treat
ed psychiatric disorder. There is now good evidence that antidepressan
t medication, including tricyclic antidepressants, selective serotonin
reuptake inhibitors, and monoamine oxidase inhibitors, are effective
in treating both the depressive symptomatology and social impairments
of chronic depression. Long-term studies in progress suggest that anti
depressant medications are also effective in sustaining recovery durin
g the maintenance treatment of chronic depression.