CHIRAL DISCRIMINATION BY HPLC ON ARYL CARBAMATE DERIVATIVES OF CHITINCOATED ONTO MICROPOROUS AMINOPROPYL SILICA

Authors
CASS QB BASSI AL MATLIN SA
Citation
Qb. Cass et al., CHIRAL DISCRIMINATION BY HPLC ON ARYL CARBAMATE DERIVATIVES OF CHITINCOATED ONTO MICROPOROUS AMINOPROPYL SILICA, Chirality, 8(1), 1996, pp. 131-135
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
8
Issue
1
Year of publication
1996
Pages
131 - 135
Database
ISI
SICI code
0899-0042(1996)8:1<131:CDBHOA>2.0.ZU;2-3
Abstract
Optical resolution of a range of racemic compounds was investigated us ing bis(aryl carbamate) derivatives of chitin coated onto microporous organosilane-modified silica. The influence on chiral discrimination o f factors such as the carbamate/support weight ratio, the nature of po lysaccharide, and the influence of the aryl group substituents was inv estigated. The bis(3,5-dimethylphenyl carbamate) derivative of a nonco mmerical chitin gave the best results. (C) 1996 Wiley-Liss, Inc.