CARBOHYDRATE CARBAMATE COATED ONTO MICROPOROUS SILICA - APPLICATION TO CHIRAL ANALYSIS OF COMMERCIAL PHARMACEUTICAL DRUGS

Authors
CASS QB BASSI AL CALAFATTI SA MATLIN SA TIRITAN ME DECAMPOS LMM
Citation
Qb. Cass et al., CARBOHYDRATE CARBAMATE COATED ONTO MICROPOROUS SILICA - APPLICATION TO CHIRAL ANALYSIS OF COMMERCIAL PHARMACEUTICAL DRUGS, Chirality, 8(1), 1996, pp. 143-146
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
8
Issue
1
Year of publication
1996
Pages
143 - 146
Database
ISI
SICI code
0899-0042(1996)8:1<143:CCCOMS>2.0.ZU;2-1
Abstract
The enantioselectivity of a series of chiral analytes was examined on tris-(3,5-dimethylphenyl carbamate) coated onto microporous APS-silica . The effects of the nature of the carbohydrate, the weight ratio of c arbamate/support and the type of alcohol present in the mobile phase w ere investigated. Among the chiral analytes examined, propanolol showe d an extremely good resolution. The resolution of tetramisole was opti mized and the method developed was shown to be suitable for analysis o f the drug in commercial tablets and in a suspension. (C) 1996 Wiley-L iss, Inc.