ACTIVITY PROFILES OF ANTIMUTAGENS - IN-VITRO AND IN-VIVO DATA

In this review, retinol, chlorophyllin, and N-acetylcysteine are exami ned and compared with regard to their antimutagenic activity against s ome promutagens and a group of direct-acting alkylating agents. The pr omutagens included aflatoxin B-1, certain polycyclic aromatic hydrocar bons (e.g., benzo[a]pyrene), and certain heterocyclic amines (e.g., fo od pyrolysates). Results of antimutagenicity testing selected from dat a surveyed in the published literature are displayed graphically as ac tivity profiles of antimutagens showing both the doses tested and the extent of inhibition or enhancement of mutagenic activity. All three a ntimutagens are discussed in terms of their putative mechanisms of act ion in vitro and in vivo with emphasis on the xenobiotic metabolizing enzyme systems.