PLANT ACTIVATION AND ITS ROLE IN ENVIRONMENTAL MUTAGENESIS AND ANTIMUTAGENESIS

This paper reviews the use of in vitro and in vivo antimutagenicity st udies that determined the role of plant peroxidases in the activation of arylamine promutagens. New information presented here suggests a mo del in which tobacco cell peroxidases exuded into the culture medium u ndergo a maturation process affecting their capacity to activate aryla mine promutagens. Tobacco cell peroxidases are present in medium recov ered from stationary phase cells and are associated with a fraction th at sediments at 12 000 X g. These peroxidases have a greater capacity to activate arylamines than do peroxidases present in the supernatant fluid. These data suggest that the plant activation of arylamines into products that are mutagenic in Salmonella typhimurium may be intimate ly involved in the process of lignification.