LAGUNAPYRONES A-C - CYTOTOXIC ACETOGENINS OF A NEW SKELETAL CLASS FROM A MARINE SEDIMENT BACTERIUM

Authors
LINDEL T JENSEN PR FENICAL W
Citation
T. Lindel et al., LAGUNAPYRONES A-C - CYTOTOXIC ACETOGENINS OF A NEW SKELETAL CLASS FROM A MARINE SEDIMENT BACTERIUM, Tetrahedron letters, 37(9), 1996, pp. 1327-1330
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
9
Year of publication
1996
Pages
1327 - 1330
Database
ISI
SICI code
0040-4039(1996)37:9<1327:LA-CAO>2.0.ZU;2-U
Abstract
The structures of the lagunapyrones A-C (1-3), novel, cytotoxic alpha- pyrones, produced in fermentation by a marine bacterium, have been ass igned on the basis of comprehensive spectroscopic analyses. Transforma tion of lagunapyrone B (2) to its [1', 3'-C-13(2)]-labelled acetonide allowed the relative stereochemistry of the flexible 1,3-diol moiety t o be determined.