DESIGN AND SYNTHESIS OF NOVEL PROTEASE INHIBITORS - TRIPEPTIDE ALPHA',BETA'-EPOXYKETONES AS NANOMOLAR INACTIVATORS OF THE PROTEASOME

Authors
SPALTENSTEIN A LEBAN JJ HUANG JJ REINHARDT KR VIVEROS OH SIGAFOOS J CROUCH R
Citation
A. Spaltenstein et al., DESIGN AND SYNTHESIS OF NOVEL PROTEASE INHIBITORS - TRIPEPTIDE ALPHA',BETA'-EPOXYKETONES AS NANOMOLAR INACTIVATORS OF THE PROTEASOME, Tetrahedron letters, 37(9), 1996, pp. 1343-1346
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
9
Year of publication
1996
Pages
1343 - 1346
Database
ISI
SICI code
0040-4039(1996)37:9<1343:DASONP>2.0.ZU;2-T
Abstract
Tripeptide alpha',beta'-epoxyketones were prepared stereospecifically starting from Boc-[S]-phenylalanine. Diastereomer 5b inhibited the chy motrypsin-like activity of porcine endothelial cell derived proteasome at low nanomolar concentrations.