STUDIES ON LACTAMS .99. FUSED TRICYCLIC BETA-LACTAMS VIA INTRAMOLECULAR ARYL RADICAL CYCLIZATION

Authors
BANIK BK SUBBARAJU GV MANHAS MS BOSE AK
Citation
Bk. Banik et al., STUDIES ON LACTAMS .99. FUSED TRICYCLIC BETA-LACTAMS VIA INTRAMOLECULAR ARYL RADICAL CYCLIZATION, Tetrahedron letters, 37(9), 1996, pp. 1363-1366
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
9
Year of publication
1996
Pages
1363 - 1366
Database
ISI
SICI code
0040-4039(1996)37:9<1363:SOL.FT>2.0.ZU;2-7
Abstract
Easy access to fused tricyclic beta-lactams starting with o-bromobenza ldehyde and allyl amine has been devised using intromolecular aryl rad ical cyclization under the influence of tributyltin hydride. The major product resulted from exo cyclization leading to the formation of a 6 -membered ring and thus a tricyclic beta-lactam. In some cases a minor product was a 7-membered ring-containing tricyclic beta-lactam formed by endo cyclization.