Therapy of pyoderma gangrenosum can be complicated by side effects of
the various systemic therapies, including corticosteroids, azathioprin
and cyclosporin A. In this paper we report on a 49-year-old patient p
resenting with recalcitrant pyoderma gangrenosum who was treated succe
ssfully by topical application of cyclosporin A. Cyclosporin A serum l
evels were always in the subtherapeutic range, and no side effects wer
e observed.