Mycoplasma hominis is a significant pathogen in immunocompromised host
s, particularly organ transplant recipients, We describe two recipient
s of lung allografts from the same donor who had M. hominis pleuropulm
onary infection during the immediate postoperative period, The most li
kely source of infection in these cases was the donor's respiratory tr
act, The slow-growing pinpoint colonies formed by M. hominis on routin
e bacterial culture medium may be easily overlooked and should be subc
ultured to mycoplasmal medium for definitive identification, The recom
mended management of this infection consists of drainage and antimicro
bial therapy with tetracycline, clindamycin, or a fluoroquinolone, Thi
s report highlights the potential for M. hominis to be transmitted fro
m donor to recipient during organ transplantation.