GOSERELIN DEPOT VERSUS DANAZOL IN THE TREATMENT OF ENDOMETRIOSIS - THE AUSTRALIAN NEW-ZEALAND EXPERIENCE

A multicentre, open, randomized comparison of depot goserelin versus d anazol to treat endometriosis was undertaken in 9 Australian/New Zeala nd centres. The study compared the effects of the 2 drugs on subjectiv e and objective parameters in women with symptomatic and/or infertilit y associated endometriosis. The duration of treatment was 24 weeks wit h either depot goserelin acetate, 3.6 mg, subcutaneously at 4-weekly i ntervals or danazol, 600 mg/day. As shown in previous studies, depot g oserelin and danazol were equally effective in reducing endometriosis scores and pain. Patients in our study showed considerably more intole rance of study drugs, particularly danazol, than women in American and European reports: 19 of 36 women randomized to danazol in our study f ailed to complete 6 months therapy, because of adverse events (9/36) o r because of unwillingness to continue with therapy (8/36). Consumer s atisfaction with medical treatment for endometriosis was an important issue in this study.